How Have Advanced Drug Modalities Impacted Bioanalysis?
As therapeutic drugs have grown in complexity, so too have the bioanalysis techniques to support these products. Bioanalysis of small molecule drugs has become more routine over time with the accumulation of experience gained through decades of work. The advent of large molecule therapeutics ushered in all new challenges as protein-based immunoassays became the norm. These assays tend to be less robust than those used for small molecule work and more variable due to the nature of the methodologies required. However, regulated immunoassays to support large molecules have continued to be a major area of work in the industry and our collective experience with them has grown considerably.